Kato H, Nishida K, Yoshida A, Takada I, McCown C, Matsuo M, et al. How to apply Larsen score in evaluating radiographs of rheumatoid arthritis in long-term studies. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Radiological assessment of osteo-arthrosis. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. 2008 214:515–22.Īrnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N, et al. Haem oxygenase-1 regulates catabolic and anabolic processes in osteoarthritic chondrocytes. Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes. Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis. Kobayashi H, Takeno M, Saito T, Takeda Y, Kirino Y, Noyori K, et al. Heart failure increases protein expression and enzymatic activity of heme oxygenase-1 in the lung. Lam CF, Croatt AJ, Richardson DM, Nath KA, Katusic ZS. Heme oxygenase and the cardiovascular-renal system. Heme oxygenase-1 alleviates ischemia/reperfusion injury in aged liver. Wang XH, Wang K, Zhang F, Li XC, Li J, De W, et al. ![]() Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. ![]() Implication of processed pseudogenes derived from heme oxygenase-2 gene. Characterization of rat heme oxygenase-3 gene. Hayashi S, Omata Y, Sakamoto H, Higashimoto Y, Hara T, Sagara Y, et al. The role of cytokines in the pathogenesis of rheumatoid arthritis. Lipsky PE, Davis LS, Cush JJ, Oppenheimer-Marks N. In: Pathological basis of the connective tissue diseases. Rheumatoid arthritis: cell and tissue pathology. The correlation of HO-1 concentration in synovial fluid with serum CRP and MMP-3 in joint fluid indicated that HO-1 might be useful as a marker of joint inflammation in RA patients. These results indicated that HO-1 expression in synovial tissue might be stimulated by inflammatory cytokines. HO-1 protein levels in cultured media of RASFs were increased by stimulation by interleukin-1β at 6 h and tumor necrosis factor-alpha at 12 h, but suppressed by interferon-gamma at 12 and 24 h. Positive immunoreaction for HO-1 was observed in cells of synovial tissue including synovial fibroblasts and cells in synovial pannus. There was weak correlation between the levels of HO-1 protein and MMP-3 in synovial fluid in the RA group ( r = 0.31, P < 0.01), while no positive correlation was observed in OA. ![]() Higher levels of HO-1 were seen in the RA-L group (Larsen grade III–V) than in the RA-E (Larsen grade 0-II) group ( P < 0.001). HO-1 levels in synovial fluid were higher in the RA group than in the OA group with significant difference ( P < 0.001), and correlated with serum C-reactive protein (CRP) level ( r = 0.80, P < 0.01) in the RA group. HO-1 production by RASFs in response to various cytokines was examined by ELISA. Synovial tissues obtained from RA or OA patients during total knee arthroplasty (TKA) were used for immunohistochemical analysis of HO-1. Synovial fluid samples were obtained from knee joints of 20 rheumatoid arthritis (RA) and 20 osteoarthritis (OA) patients, and concentration of HO-1 and matrix metalloproteinase-3 (MMP-3) were measured by enzyme-linked immunosorbent assay (ELISA). We investigated the expression and localization of heme oxygenase-1 (HO-1) in synovial fluid and synovial tissue, and examined the stimulation of HO-1 production in rheumatoid synovial fibroblasts (RASFs).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |